the blood protein involved in blood coagulation is

get the blood protein involved in blood coagulation is from screen.

Blood Clotting Proteins

'Blood Clotting Proteins' published in 'Encyclopedia of Metalloproteins'

Blood Clotting Proteins

Sheryl R. Bowley, Mingdong Huang, Barbara C. Furie & Bruce Furie M.D.

Reference work entry

449 Accesses

Synonyms

: epidermal growth factor-like domain; : Γ-carboxyglutamic acid; : procoagulant cofactors

Definitions

: blood clotting

: γ-carboxyglutamic acid is formed by posttranslational addition of a carboxyl group to the γ-carbon of glutamic acid

: formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system

: proteins whose binding to another coagulation protein requires proteolytic cleavage for full activity of the complex

: a complex formed by the assembly of factors IXa and VIIIa on a cell membrane that converts factor X to active factor Xa

: a complex formed by the association of factors Va and Xa on a cell membrane that converts prothrombin to thrombin

: a protein domain conserved through evolution that includes an N-terminal two-stranded beta-sheet followed by a loop and a short C-terminal two-stranded beta-sheet

Bloo...

This is a preview of subscription content, access via your institution.

Buying options

Chapter EUR   29.95

Price includes VAT (Turkey)

eBook EUR   750.00

Price includes VAT (Turkey)

Hardcover Book EUR   799.99

Price excludes VAT (Turkey)

Learn about institutional subscriptions

References

Adams TE, Hockin MF, Mann KG, Everse SJ (2004) The crystal structure of activated protein C-inactivated bovine factor Va: implications for cofactor function. Proc Natl Acad Sci USA 101:8918–8923

CrossRef PubMed CAS Google Scholar

Banner DW, D'Arcy A, Chene C, Winkler FK, Guha A, Konigsberg WH, Nemerson Y, Kirchhofer D (1996) The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor. Nature 380:41–46

CrossRef PubMed CAS Google Scholar

Furie B, Furie BC (2008) Mechanisms of thrombus formation. N Engl J Med 359:938–949

CrossRef PubMed CAS Google Scholar

Huang M, Rigby AC, Morelli X, Grant MA, Huang G, Furie B, Seaton B, Furie BC (2003) Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins. Nat Struct Biol 10:751–756

CrossRef PubMed CAS Google Scholar

Huang M, Furie BC, Furie B (2004) Crystal structure of the calcium-stabilized human factor IX Gla domain bound to a conformation-specific anti-factor IX antibody. J Biol Chem 279:14338–14346

CrossRef PubMed CAS Google Scholar

Kollman JM, Pandi L, Sawaya MR, Riley M, Doolittle RF (2009) Crystal structure of human fibrinogen. Biochemistry 48:3877–3886

CrossRef PubMed CAS Google Scholar

Komaromi I, Bagoly Z, Muszbek L (2011) Factor XIII: novel structural and functional aspects. J Thromb Haemost 9(1):9–20

CrossRef PubMed CAS Google Scholar

Ngo JC, Huang M, Roth DA, Furie BC, Furie B (2008) Crystal structure of human factor VIII: implications for the formation of the factor IXa-factor VIIIa complex. Structure 16:597–606

CrossRef PubMed CAS Google Scholar

Pratt KP, Shen BW, Takeshima K, Davie EW, Fujikawa K, Stoddard BL (1999) Structure of the C2 domain of human factor VIII at 1.5 Å resolution. Nature 402:439–442

CrossRef PubMed CAS Google Scholar

Shen BW, Spiegel PC, Chang CH, Huh JW, Lee JS, Kim J, Kim YH, Stoddard BL (2008) The tertiary structure and domain organization of coagulation factor VIII. Blood 111:1240–1247

CrossRef PubMed CAS Google Scholar

Soriano-Garcia M, Padmanabhan K, de Vos AM, Tulinsky A (1992) The Ca2+ ion and membrane binding structure of the Gla domain of Ca-prothrombin fragment 1. Biochemistry 31:2554–2566

CrossRef PubMed CAS Google Scholar

Weisel JW (2005) Fibrinogen and fibrin. Adv Protein Chem 70:247–299

CrossRef PubMed CAS Google Scholar Download references

Author information

Authors and Affiliations

Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, 02115, Boston, MA, USA

Dr. Sheryl R. Bowley, Dr. Mingdong Huang, Dr. Barbara C. Furie & Bruce Furie M.D.

Corresponding author

Correspondence to Bruce Furie M.D. .

Editor information

Editors and Affiliations

Department of Biology, University of Virginia, Charlottesville, VA, USA

Robert H. Kretsinger

Department of Molecular Medicine, College of Medicine, University of South Florida, Tampa, FL, USA

Vladimir N. Uversky

Institute for Biological Instrumentation, Russian Academy of Sciences, Pushchino, Moscow Region, Russia

Eugene A. Permyakov

Rights and permissions

Reprints and Permissions

Copyright information

© 2013 Springer Science+Business Media New York

About this entry

Cite this entry

Bowley, S.R., Huang, M., Furie, B.C., Furie, B. (2013). Blood Clotting Proteins. In: Kretsinger, R.H., Uversky, V.N., Permyakov, E.A. (eds) Encyclopedia of Metalloproteins. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1533-6_46

Download citation

.RIS.ENW.BIB DOI

https://doi.org/10.1007/978-1-4614-1533-6_46

स्रोत : link.springer.com

Blood protein which initiates blood coagulation is

Click here👆to get an answer to your question ✍️ Blood protein which initiates blood coagulation is

Question

Blood protein which initiates blood coagulation is

A

Prothrombin

B

Thrombin

C

Fibrinogen

D

Fibrin

Medium Open in App

Updated on : 2022-09-05

Solution Verified by Toppr

Correct option is A)

Prothrombin is a plasma protein essential for blood clotting. Whenever there is an injury, prothrombin activator complex is formed. Prothrombin is converted into thrombin by activators. Thrombin acts as an enzyme and converts plasma protein fibrinogen into fibrin threads which form a clot at the site of injury and bleeding is stopped.

So, the correct answer is 'Prothrombin'.

Solve any question of Body Fluids and Circulation with:-

Patterns of problems

>

Was this answer helpful?

1 1

स्रोत : www.toppr.com

Blood protein which initiates blood coagulation isA) ProthrombinB) ThrombinC) FibrinogenD) Fibrin

Blood protein which initiates blood coagulation isA) ProthrombinB) ThrombinC) FibrinogenD) Fibrin. Ans: Hint: Coagulation is also known as blood clotting. In this process the blood changes from liquid to gel. The thickening of blood is caused due to...

Blood protein which initiates blood coagulation is

A) Prothrombin B) Thrombin C) Fibrinogen D) Fibrin

Last updated date: 14th Mar 2023

• Total views: 249.6k • Views today: 4.30k Answer Verified 249.6k+ views 1 likes

Hint: Coagulation is also known as blood clotting. In this process the blood changes from liquid to gel. The thickening of blood is caused due to an injury. It results in the stoppage of the blood loss from the site of injury.Complete answer:

To answer this question, we must know about the process of blood clotting. Blood clotting takes place at the site of injury. It results in the thickening of the blood which causes cessation of the blood loss from the site of injury.

Platelets present in the blood are responsible for the process of clotting. The mechanism of clotting is initiated by the prothrombin. The various steps involved in blood clotting are-

>The clotting factors convert the blood protein prothrombin to activate thrombin.

>The thrombin further converts the fibrinogen into fibrin.

>This fibrin forms a network and traps RBC and platelets at the site of injury and forms a clot.

-Thrombin- It is the principal enzyme for blood clotting. It converts the fibrinogen to fibrin.

-Fibrinogen- It is a glycoprotein made by the liver. It circulates in the blood of all vertebrates.

-Fibrin- It is a mesh like network which forms at the site of injury and thus stops bleeding.

Hence, the correct answer is option ‘A’.Note: The clotting requires coagulation factors, calcium and phospholipids. Prothrombin is a plasma protein essential for blood clotting. Prothrombin is a protein manufactured by the liver. There are 13 essential coagulation factors required for the process of clotting.

स्रोत : www.vedantu.com