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    which compound forms carboxyhemoglobin when compines with blood?


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    Compound that combines with haemoglobin of blood to form carboxy haemoglobin is:

    Click here👆to get an answer to your question ✍️ Compound that combines with haemoglobin of blood to form carboxy haemoglobin is:


    Compound that combines with haemoglobin of blood to form carboxy haemoglobin is:


    2 ​ O


    2 ​


    2 ​



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    Correct option is D)

    The highly toxic nature of CO arises due to the fact that it easily forms a complex with haemoglobin called carboxy-haemoglobin which is more stable than oxy-haemoglobin disrupting the oxygen supply in the body.

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    What is the compound formed when CO combines with class 11 chemistry CBSE

    What is the compound formed when CO combines with hemoglobin

    What is the compound formed when

    CO CO

    combines with hemoglobin?

    Answer Verified 96.3k+ views

    Hint: Haemoglobin is a protein whose main function is to transport oxygen from the lungs to the tissues and to transport carbon dioxide gas from the tissues to the lungs. Carbon monoxide is a colorless, tasteless, odorless and flammable gas. It is harmful when inhaled because it displaces oxygen in the blood.Complete answer:

    Carbon monoxide combines with hemoglobin to form carboxyhemoglobin. It also acts to increase the stability of the bond between oxygen and hemoglobin, reducing the ability of the hemoglobin molecule to release oxygen bound to other oxygen binding sites. The overall result is a decrease in the oxygen available to the tissues present in the body. Carboxyhemoglobin is a stable complex of carbon monoxide and hemoglobin that forms in red blood cells on contact with carbon monoxide. Compared to oxygen, carbon monoxide binds with approximately

    240 240

    times higher affinity. Increase in the levels of carboxyhemoglobin results in various degrees of asphyxiation, including death. It does not dissociate readily. As a result, the oxygen carrying power of blood gets limited. A high level of carboxyhemoglobin is the cause of death in carbon monoxide poisoning as from car exhaust.

    Therefore, the compound formed when

    CO CO

    combines with hemoglobin is carboxyhemoglobin.


    A carbon monoxide blood test helps to detect carbon monoxide poisoning. Poisoning can happen if we breathe air that contains more carbon monoxide. The test measures the amount of hemoglobin that has bonded with carbon monoxide gas. This is known as the carboxyhemoglobin level.

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    From Wikipedia, the free encyclopedia

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    Not to be confused with carbaminohemoglobin, the compound formed when CO

    2 binds with hemoglobin.



    Preferred IUPAC name

    Carbonylhemoglobin Other names Carboxyhemoglobin Carboxyhaemoglobin







    Carbonic oxide hæmoglobin

    Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

    Infobox references

    Carboxyhemoglobin, or carboxyhaemoglobin, (symbol COHb or HbCO) is a stable complex of carbon monoxide and hemoglobin (Hb) that forms in red blood cells upon contact with carbon monoxide. Carboxyhemoglobin is often mistaken for the compound formed by the combination of carbon dioxide (carboxyl) and hemoglobin, which is actually carbaminohemoglobin. Carboxyhemoglobin terminology emerged when carbon monoxide was known by its ancient name carbonic oxide and evolved through Germanic and British English etymological influences; the preferred IUPAC nomenclature is carbonylhemoglobin.[2][3][4]

    The average non-smoker maintains a systemic carboxyhemoglobin level under 3% COHb whereas smokers approach 10% COHb.[4] The biological threshold for carboxyhemoglobin tolerance is 15% COHb, meaning toxicity is consistently observed at levels in excess of this concentration.[5] The FDA has previously set a threshold of 14% COHb in certain clinical trials evaluating the therapeutic potential of carbon monoxide.[6]


    1 Overview

    2 Endogenous carbon monoxide production

    3 Affinity of hemoglobin for carbon monoxide

    4 History 4.1 Etymology

    5 Analytical detection methods

    6 Carbon monoxide poisoning

    6.1 Mode of toxic action

    6.2 Toxicokinetics

    7 Carboxyhemoglobin pharmaceuticals

    8 See also 9 References 10 External links


    The average red blood cell contains 250 million hemoglobin molecules.[7] Hemoglobin contains a globin protein unit with four prosthetic heme groups (hence the name heme -o- globin); each heme is capable of reversibly binding with one gaseous molecule (oxygen, carbon monoxide, cyanide, etc.),[8] therefore a typical red blood cell may carry up to one billion gas molecules. As the binding of carbon monoxide with hemoglobin is reversible, certain models have estimated that 20% of the carbon monoxide carried as carboxyhemoglobin may dissociate in remote tissues.[7]

    Endogenous carbon monoxide production[edit]

    In biology, carbon monoxide is naturally produced through many enzymatic and non-enzymatic pathways.[7] The most extensively studied pathway is the metabolism of heme by heme oxygenase which occurs throughout the body with significant activity in the spleen to facilitate hemoglobin breakdown during erythrocyte recycling. Therefore heme can both carry carbon monoxide in the case of carboxyhemoglobin, or, undergo enzymatic catabolism to generate carbon monoxide.

    Carbon monoxide was characterized as a neurotransmitter in 1993 and has since been subcategorized as a gasotransmitter.[4]

    Most endogenously produced carbon monoxide is stored as carboxyhemoglobin. The gas primarily undergoes pulmonary excretion, however trace amounts may be oxidized to carbon dioxide by certain cytochromes, metabolized by resident microbiota, or excreted by transdermal diffusion.[4][7]

    Affinity of hemoglobin for carbon monoxide[edit]

    Compared to oxygen, carbon monoxide binds with approximately 240 times greater affinity,[9][4] however the affinity of carbon monoxide for hemoglobin varies both across species and within a species. In the 1950s, Esther Killick was among the first to recognize a difference in carbon monoxide affinity between adult and foetal blood, and a difference between humans and sheep.[4][10][11] In humans, the Hb-Kirklareli mutation has a relative 80,000 times greater affinity for carbon monoxide than oxygen resulting in systemic carboxyhemoglobin reaching a sustained level of 16% COHb.[5] Other human mutations have been described (see also: hemoglobin variants).[12][13] Structural variations and mutations across other hemoproteins likewise affect carbon monoxide's interaction with the heme prosthetic group as exemplified by Cytochrome P450 where certain forms of the CYP3A family is relatively less affected by the inhibitory effects of carbon monoxide.[4]

    Murinae species have a COHb half-life of 20 minutes compared to 300 minutes for a typical human (see toxicokinetics below).[4] As a result, the metabolic kinetics, blood saturation point, and tolerance for carbon monoxide exposure vary across species, potentially leading to data inconsistencies pertaining to the toxicology of carbon monoxide poisoning and pharmacology of low-dose therapeutic protocols.[4]

    Some deep-diving marine mammal species are known to contain concentrations of carbon monoxide in their blood that resembles levels seen in chronic cigarette smokers, which may provide benefits against hypoxia.[14] Similarly, the elevated levels in smokers has been suggested to be a basis for the smoker's paradox.[4] Prolonged exposure to carbon monoxide and elevated carboxyhemoglobin, such as in smoking, results in erythremia.[4] Furthermore, humans can acclimate to toxic levels of carbon monoxide based on findings reported by Esther Killick.[4]

    स्रोत : en.wikipedia.org

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